Estimated creatinine excretion per day (CKD epidemiology collaboration) - Evidencio
Estimated creatinine excretion per day (CKD epidemiology collaboration)
This model estimates an individual's expected daily creatinine excretion. Knowledge of the normal rate of creatinine excretion can be applied to assess completeness of the 24 hr urine collection.
Research authors: Ix JH, Wassel CL, Stevens LA, Beck GJ, Froissart M, Navis G, Rodby R, Torres VE, Zang YL, Greene T, Levey AS.
Version: 1.21
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Estimated creatinine excretion (ECR): mg/day

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How this model should be used: 
Creatinine excretion rate (CER) indicates timed urine collection accuracy. Although equations to estimate CER exist, their bias and precision are untested and none simultaneously include age, sex, race, and weight.

Model limitations: 
Caution should be used in using the equations in patients without kidney disease and in persons with muscle mass outside of population norms.

Model performance upon internal validation: 
Performance of the newly developed equation was assessed in internal (N=822) and external (N=987) validation data sets. Little bias (<1%) was observed in the internal validation data set. Precision was moderate (interquartile range around the percent difference was 26%). For accuracy, the measured CER was within 15% of the expected CER (P15) among 59% of individuals, and within 30% of  expected CER (P30) among 85% of individuals. 

Source: 
Ix JH, Wassel CL, Stevens LA, et al. Equations to estimate creatinine excretion rate: the CKD epidemiology collaboration. Clin J Am Soc Nephrol. 2011;6(1):184-91.

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This algorithm is provided for educational, training and information purposes. It must not be used to support medical decision making, or to provide medical or diagnostic services. Read our full disclaimer.

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