Adjusted anion-gap calculator, corrected for albumin.
Calculates the adjusted serum anion-gap, corrected for the influence of co-existing hypoalbuminemia or hyperalbuminemia.
Research authors: Feldman M, Soni N, Dickson B.
Version: 1.14
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  • Clinical pharmacology
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The albumin-adjusted anion-gap is: mmol/l

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Conditional information

Reference values:
An adjusted anion-gap of 8 +/- 3 mmol/l is considered normal.

How this model should be used: 
Before considering whether a disorder associated with an increased or decreased anion gap is present, the anion gap should be first adjusted for abnormal serum albumin concentrations. In a study by Feldman et al (2005) in 5328 consecutive patients, highly significant correlations between either serum albumin or total protein and the anion gap were reported (P < 0.001). The initial assessment of an anion gap as being increased, normal, or decreased changed in 44% of the patients with hypo- or hyperalbuminemia once anion gap had been adjusted with the abovementioned formula.

Important notice:
The anion-gap can vary widely, reflecting both differences in the methods that are used to measure its constituents and substantial interindividual variability.

Source:
Feldman et al. Influence of hypoalbuminemia or hyperalbuminemia on the serum anion gap. J Lab Clin Med. 2005;146(6):317-20.

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This model is provided for educational, training and information purposes. It must not be used to support medical decision making, or to provide medical or diagnostic services. Read our full disclaimer.

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