Calculating drug steady state achieved (hours) - Evidencio
Calculating drug steady state achieved (hours)
The steady state of drug intake regards a constant mean concentration of a drug in which the elimination and absorption of the drug is equal. The time to achieve steady state is relying on the half-life of the drug. This formula can be used to quickly assess how long it would take to achieve steady state.

Mostly, 4-5 half-lives are used to achieve clinical steady state
Research authors: None
Version: 1.5
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Time to achieve steady state is hours

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If the time to achieve steady state is longer than desired, an initial loading dose of a drug can be administered to reach the desired blood concentration quickly.
Note: The loading dose is based on the volume of distribution and the maintenance dose is based on the half-life of the drug administered. 

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This algorithm is provided for educational, training and information purposes. It must not be used to support medical decision making, or to provide medical or diagnostic services. Read our full disclaimer.

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