CLIF-C AD: Acute decompensatio score and mortality rate. - Evidencio
CLIF-C AD: Acute decompensatio score and mortality rate.
The CLIF Consortium Acute Decompensation score (CLIF-C ADs) for prognosis of hospitalised cirrhotic patients without acute-on-chronic liver failure:

Cirrhotic patients with acute decompensation frequently develop acute-on-chronic liver failure (ACLF), which is associated with high mortality rates. Recently, a specific score for these patients has been developed using the CANONIC study database. The aims of this study were to develop and validate the CLIF-C AD score, a specific prognostic score for hospitalised cirrhotic patients with acute decompensation (AD), but without ACLF, and to compare this with the Child-Pugh, MELD, and MELD-Na scores.
Research authors: Rajiv Jalan, Marco Pavesi, Faouzi Saliba, Alex Amorós, Javier Fernandez, Peter Holland-Fischer, Rohit Sawhney, Rajeshwar Mookerjee, Paolo Caraceni, Richard Moreau, Pere Ginès, Francois Durand, Paolo Angeli, Carlo Alessandria, Wim Laleman, Jonel Trebicka, Didier Samuel, Stefan Zeuzem, Thierry Gustot, Alexander L. Gerbes, Julia Wendon, Mauro Bernardi, Vicente Arroyo
Version: 1.11
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The new CLIF-C ADs is more accurate than other liver scores in predicting prognosis in hospitalised cirrhotic patients without ACLF. CLIF-C ADs therefore may be used to identify a high-risk cohort for intensive management and a low-risk group that may be discharged early.

C-statistics at 90 days is: 0.743 (CI 95%: 0.704 0.783)
C-statistics at 180 days is: 0.711 (CI 95%: 0.675 0.747)
C-statistics at 365 days is: 0.670 (CI 95%: 0.639 0.702)

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