EASIX-GVHD score in patients with acute GVHD after allogenic stem-cell transplantation
Endothelial dysfuntion links thrombotic microangiopathy to steroid-refractory graft-versus-host disease (GVHD) after allogeneic stem-cell transplantation. The Endothelial Activation and Stress Index (EASIX) calculates the risk of death in patients with acute GVHD after allogeneic stem-cell transplantation.
Research authors: Luft T, Benner A, Jodele S, Dandoy CE, Storb R, Gooley T, Sandmaier BM, Becker N, Radujkovic A, Dreger P, and Penack O.
Version: 1.7
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Context information:
The present clinical application of EASIX-GVHD is an easy-to-use prediction of acute GVHD mortality in patients who have undergone RIC alloSCT, raising awareness of the endothelial nature of the problem. The tool provides a tool for studies with these therapeutic approaches and could be the future basis for development of risk-adapted GVHD treatment strategies. The EASIX-GVHD score, measured at the onset of acute GVHD, can be applied to predict overall and non-relapse mortality in patients with GVHD who had undergone reduced-intensity conditioning (RIC).

Model validation: 
The EASIX-GVHD model was based on a training cohort of 311 patients and subsequently validated on the Berlin, Seattle, and Cincinnati cohorts (external validation). 
A prospecitve validation study for the EASIX-GVHD is underway. To address another possible clinical application, the authors of the orignal EASIX-GVHD are currently performing retrospective analyses of EASIX taken before start of conditioning as a predictor of alloSCT outcome.

References: 
Luft T, Benner A, Jodele S, et al. EASIX in patients with acute graft-versus-host disease: a retrospective cohort analysis. Lancet Haematol. 2017. pii: S2352-3026(17)30108-4.

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This model is provided for educational, training and information purposes. It must not be used to support medical decision making, or to provide medical or diagnostic services. Read our full disclaimer.

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