Nottingham prognostische index (update 2007): borstkanker-specifieke 10-jaa - Evidencio
Nottingham prognostische index (update 2007): borstkanker-specifieke 10-jaarsoverleving bij patiënten met primair mammacarcinoom
De Nottingham prognostische index werd ontwikkeld in 1982. Sindsdien is de gemiddeld overleving van patiënten met primair mammacarcinoom aanzienlijk verbeterd. Deze modelupdate van Blamey et al. (2007) stratificeert patiënten in zes verschillende risicocategorieën op basis van data van 2238 patiënten uit de periode 1990-1999. 
Research authors: Blamey RW, Ellis IO, Pinder SE, Lee AH, Macmillan RD, Morgan DA, Robertson JF, Mitchell MJ, Ball GR, Haybittle JL, en Elston CW.
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Borstkanker-specifieke 10-jaars overleving (update NPI): %

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Aanwijzingen voor toepassing van de NPI:
De Nottingham prognostische index (NPI) werd reeds in 1982 ontwikkeld.1 Sindsdien is de gemiddeld overleving van patiënten met primair mammacarcinoom aanzienlijk verbeterd. Deze modelupdate van Blamey et al. (2007) stratificeert patiënten in zes verschillende risicocategorieën op basis van data van 2238 patiënten uit de periode 1990-1999. Deze indeling in risicocategorieën kan ondersteunen bij het selecteren van laag- en hoog-risco patiënten, op basis waarvan arts en patiënt gezamenlijk kunnen komen tot een passend behandelplan (shared-decision making). 

Model prestaties
In een externe validatiestudie van Blamey et al.bleek de NPI in staat tot het adequaat stratificeren van patiënten met primair mammacarcinoom in zes verschillende risicocategorieën (Figuur 1).

Bronnen: 

  1. Haybittle JL, Blamey RW, Elston CW, et al. A prognostic index in primary breast cancer. Br J Cancer. 1982;45(3):361-6.
  2. Blamey RW, Ellis IO, Pinder SE, et al. Survival of invasive breast cancer according to the Nottingham Prognostic Index in cases diagnosed in 1990-1999. Eur J Cancer. 2007;43(10):1548-55.

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