Nottingham Prognostic Index - Evidencio
Nottingham Prognostic Index
The Nottingham prognostic index is used to stratify breast cancer patients into 5 prognostic groups. It can be applied to study the effects of treatment regimes within groups of similar patients.
 
Research authors: Todd JH, Dowle C, Williams MR, Elston CW, Ellis IO, Hinton CP, Blamey RW, and Haybittle JL.
Version: 1.39
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Estimated 5-years survival based on the Nottingham Prognostic Index: %

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How this model should be used:
The Nottingham prognostic index allows physicians to select those patients with an excellent prognosis after surgery alone, in whom adjuvant therapies are inappropriate. However, those patients with high index scores may benefit from local and/or systemic adjuvant treatment, both in terms of locoregional disease control and possibly survival. 

Model performance
A prognostic index, previously derived in a group of 387 patients with primary breast cancer, has been recalculated for the same patients with over 5 years further follow-up and shown to be unchanged. The prognostic index has also been applied prospectively to a further group of 320 patients and shown to be similarly effective in identifying patients with either a very good or a very poor prognosis. It has been verified that the index applies to patients with primary breast cancer.

Source: 
Todd JH, Dowle C, Williams MR, et al. Confirmation of a prognostic index in primary breast cancer. Br J Cancer. 1987;56(4):489-92.

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