Creatinine clearance based on 24 hr collection of urine, corrected for body - Evidencio
Creatinine clearance based on 24 hr collection of urine, corrected for body surface area
Calculates creatinine clearance in mL/min corrected for body surface area (BSA) as a measure of kidney function. Height and body weight of the patients as well as a creatinine determination on both serum and a 24 hr collection of urine are required.
 
Research authors: None
Version: 1.21
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Creatinine clearance corrected for BSA: mL/min

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Background information: 
The creatinine clearance is a widely used test to estimate the glomerular filtration rate (GFR).1 Creatinine is derived from the metabolism of creatine in skeletal muscle and from dietary meat. It is released into the circulation at a relatively constant rate and has a stable plasma concentration. 

Evaluation of the creatinine clearance: 
Creatinine clearance is usually determined from a 24-hour urine collection. Shorter collections tend to give less accurate results.2 There are three major errors that can limit the accuracy of the creatinine clearance as an estimate of GFR: errors in urine collection; increases in both creatinine secretion and extrarenal creatinine degradation as the GFR falls.3

Correction for body surface area: 
Creatinine clearance should ideally be normalized to a body surface area (BSA) of 1.73 m2. In patients with a higher or lower BSA, the corrected creatinine clearance will be lower and higher, respectively.1 

Reference values: 
Typical creatinine clearance for healthy adults is 80 - 120 mL/min.

Sources: 

  1. Doolan PD, Alpen EL, Theil GB. A clinical appraisal of the plasma concentration and endogenous clearance of creatinine. Am J Med 1962; 32:65.
  2. Perrone RD, Madias NE, Levey AS. Serum creatinine as an index of renal function: new insights into old concepts. Clin Chem 1992; 38:1933.
  3. Shemesh O, Golbetz H, Kriss JP, Myers BD. Limitations of creatinine as a filtration marker in glomerulopathic patients. Kidney Int 1985; 28:830.

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This algorithm is provided for educational, training and information purposes. It must not be used to support medical decision making, or to provide medical or diagnostic services. Read our full disclaimer.

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