Creatinine clearance based on 24 hr collection of urine - Evidencio
Creatinine clearance based on 24 hr collection of urine
Calculates creatinine clearance in ml/min as a measure of kidney function. A creatinine determination on both serum and a 24 hr collection of urine is required.
Research authors: None
Version: 1.14
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  • Internal medicine
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Calculated creatinine clearance: mL/min

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Background information: 
The creatinine clearance is a widely used test to estimate the glomerular filtration rate (GFR).1 Creatinine is derived from the metabolism of creatine in skeletal muscle and from dietary meat. It is released into the circulation at a relatively constant rate and has a stable plasma concentration. 

Evaluation of the creatinine clearance: 
Creatinine clearance is usually determined from a 24-hour urine collection. Shorter collections tend to give less accurate results. One problem with shorter timed collections is that any retained urine would represent a larger percent of the total urine collection. In addition, creatinine excretion varies throughout the day.2

Reference values: 
Typical creatinine clearance for healthy adults is 80 - 120 mL/min. 

Sources: 

  1. Doolan PD, Alpen EL, Theil GB. A clinical appraisal of the plasma concentration and endogenous clearance of creatinine. Am J Med 1962; 32:65.
  2. Perrone RD, Madias NE, Levey AS. Serum creatinine as an index of renal function: new insights into old concepts. Clin Chem 1992; 38:1933.

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This algorithm is provided for educational, training and information purposes. It must not be used to support medical decision making, or to provide medical or diagnostic services. Read our full disclaimer.

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