Glomerular filtration rate (GFR) - Cockcroft & Gault formula - Evidencio
Glomerular filtration rate (GFR) - Cockcroft & Gault formula
Calculates the estimated glomerular filtration rate based on the Cockcroft & Gault formula.
Autores de la investigación: Cockcroft DW, Gault MH.
Versión: 1.23
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Estimated glomerular filtration rate: ml/min

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Información condicional

Although creatinine clearance may over-estimate GFR by 10-20%, it still remains the standard for drug dosing adjustments.

The Cockcroft-Gault equation1 should be based on body weight and body mass index (BMI), as it appears to become less accurate in weight extremes (underweight and particularly overweight/obesity). As recommended by Winter et. al2 and Brown et. al3 the following adjustments are advised:

  • Underweight (BMI < 18.5 kg/m2): Weight uses actual/total body weight (No adjustment)
  • Normal Weight (BMI 18.5 - 22.9): Weight uses ideal body weight (with the range using the actual body weight)
  • Overweight/Obese (BMI ≥ 23): Weight uses adjusted body weight (with the range using ideal body weight).


References:
1Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41.
2Winter MA, Guhr KN, Berg GM. Impact of various body weights and serum creatinine concentrations on the bias and accuracy of the Cockcroft-Gault equation. Pharmacotherapy. 2012;32(7):604-12.
3Brown DL, Masselink AJ, Lalla CD. Functional range of creatinine clearance for renal drug dosing: a practical solution to the controversy of which weight to use in the Cockcroft-Gault equation. Ann Pharmacother. 2013;47(7-8):1039-44.
 

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