Berekening benodigde hoeveelheid infuus ter correctie serum natrium (Na+) - Evidencio
Berekening benodigde hoeveelheid infuus ter correctie serum natrium (Na+)
Formule ter schatting van de benodigde hoeveelheid infuusvloeistof benodigd ter correctie van het plasma natrium (Na+).
Research authors: None
Version: 1.30
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  • Internal medicine
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Benodigde hoeveelheid van het gekozen infuus: liter in 24 uur

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Voorbeeld:
Patiënt (man, 70 kg, totaal lichaamswater 0,6 x 70 = 42 l) met acute hyponatriëmie (110 mmol/l). Plan: correctie van 12 mmol/l in 24 uur met 3% NaCl zonder KCl (bevat 513 mmol Na). Voorspelde stijging Na met 1 l 3% NaCl = (513 – 110)/(42 + 1) = 9,4 mmol/l. Dus voor gewenste correctie van 12 mmol/l wordt de benodigde hoeveelheid infuus: 12/9,4 = 1,3 l 3% NaCl/24 uur ofwel 54 ml/uur.

Referentie concentratie natrium in infuusvloeistof (in mmol per liter):

  • Glucose 5% bevat:                                               0 mmol natrium per liter.
     
  • NaCl 0,25% bevat:                                             34 mmol natrium per liter.
  • NaCl 0,45% bevat:                                             77 mmol natrium per liter.
  • NaCl 0,9% bevat:                                             154 mmol natrium per liter.
  • NaCl 2,5% bevat:                                             427 mmol natrium per liter.
  • NaCl 3,0% bevat:                                             513 mmol natrium per liter.
  • NaCl 5,0% bevat:                                             855 mmol natrium per liter.
     
  • Ringer lactaat bevat:                                        130 mmol natrium per liter.

  • NaBic 1.4% bevat:                                            167 mmol natrium per liter.
  • NaBic 4.2% bevat:                                            500 mmol natrium per liter.
  • NaBic 8.4% bevat:                                            1000 mmol natrium per liter.


Referenties:
Adrogue, HJ; and Madias, NE. Primary Care: Hypernatremia. New England Journal of
Medicine 2000; 342(20):1493-1499.
 

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