This prospective multicenter cohort study provides a prediction model for anastomotic leakage after rectal resection including CRP and MMP9 on postoperative day 3. This nomogram calculates the individual risk for anastomotic leakage after rectal resection. Assessment of model discrimination yielded a concordance index of 0.78. In addition, this model obtained good calibration with a mean absolute error of 0.025.
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