Creatinine clearance based on 24-hour urine collection - Evidencio
Creatinine clearance based on 24-hour urine collection
Calculates the creatinine clearance in ml/min as a measure of renal function. To use this model, both the serum creatinine and the amount of creatinine in the 24-hour urine sample has to be known. 
Research authors: None
Version: 1.2
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  • Internal medicine
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Calculated creatinine clearance ml/min

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Background: 
Creatinine clearance can be used as an estimate for the glomerular filtration rate (GFR).1 Creatinine is produced by the body at a fairly constant rate, depending on the amount of muscle mass present. It is mainly filtered passively in the kidney, but a small amount is actively secrated. 

Evaluation
Creatinine clearance is often estimated based on the serum creatinine in the blood or in 24-hour urine. Shorter periods of collection are possible, but often lead to less acurate results. This may be partly explained by the fact that shorter periods of collection result in a relatively high percentage of urine remaining in the bladder compared to the total volume of collected urine. Also, the secration of creatinine varies during the day.2 

Reference values: 
The creatinine clearance in healthy adults is 80-120 ml/min.

Sources: 

  1. Doolan PD, Alpen EL, Theil GB. A clinical appraisal of the plasma concentration and endogenous clearance of creatinine. Am J Med 1962; 32:65.
  2. Perrone RD, Madias NE, Levey AS. Serum creatinine as an index of renal function: new insights into old concepts. Clin Chem 1992; 38:1933.

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This algorithm is provided for educational, training and information purposes. It must not be used to support medical decision making, or to provide medical or diagnostic services. Read our full disclaimer.

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