Probability of anaphylaxis in patients with systemic mastocytosis - Evidencio
Probability of anaphylaxis in patients with systemic mastocytosis
Anaphylaxis is a common feature in patients with mastocytosis. However, not all patients with mastocytosis experience anaphylaxis. A risk analysis model for anaphylaxis was translated into a clinical scoring system.
Autores de la investigación: Gülen T, Ljung C, Nilsson G, and Akin C.
Versión: 1.18
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Total anaphylaxis risk score: points

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How this model should be used:
This risk assessment tool may provide a simple method of identifying and alerting patients with mastocytosis at high risk of anaphylaxis who would benefit from self-injectable epinephrine.

Model performance:
In the underlying study by Gülen et al (2017)1, a sensitivity of 86% (95% CI: 74.6 - 93.1%) and a specificity of 54% (95% CI: 41.8 - 65.4%) was observed in the development cohort (n=122). The corresponding postive predictive value (PPV) and negative predictive value (NPV) were 60.3% (95% CI: 49.2 - 70.7%) and 81.8% (95% CI: 68.6 - 91.2%), respectively. 

Source:

  1. Gülen T et al. Risk Factor Analysis of Anaphylactic Reactions in Patients With Systemic Mastocytosis. J Allergy Clin Immunol Pract. (2017).

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